WebGenetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40 In contrast to the promoter SNP rs4950928, the intronic SNP rs12141494 in CHI3L1 is associated with asthma severity, lung function, and YKL-40 expression in the blood and airway. WebMar 21, 2024 · GeneCards Summary for CHI3L1 Gene. CHI3L1 (Chitinase 3 Like 1) is a Protein Coding gene. Diseases associated with CHI3L1 include Asthma-Related Traits 7 …
1116 - Gene ResultCHI3L1 chitinase 3 like 1 [ (human)]
WebChitinase 3 Like 1 (CHI3L1) Promotes Vasculogenic Mimicry Formation in Cervical Cancer Vasculogenic mimicry (VM) is an alternative microvascular system which tumour cells orchestrate, independent of endothelial cell-mediated angiogenesis. WebOct 3, 2024 · Background: Chitinase-3-like protein 1 (CHI3L1) is overexpressed in various types of tumors, especially in glioma, and contributes to tumor progression. However, the definite role of CHI3L1 and involved pathway in glioma progression are not completely understood. Methods: CHI3L1 expression in human gliomas and its association with … nautilus investment research login
12654 - Gene ResultChil1 chitinase-like 1 [ (house mouse)]
WebBackground: Chitinase-3-like protein 1 (CHI3L1) is overexpressed in various types of tumors, especially in glioma, and contributes to tumor progression. However, the definite role of CHI3L1 and involved pathway in glioma progression are not completely understood. Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is a secreted glycoprotein that is approximately 40kDa in size that in humans is encoded by the CHI3L1 gene. The name YKL-40 is derived from the three N-terminal amino acids present on the secreted form and its molecular mass. YKL-40 is … See more Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This … See more YKL-40 has been linked to activation of the AKT pro-survival (anti-apoptotic) signaling pathway. YKL-40 promotes angiogenesis through VEGF-dependent and independent … See more As Alzheimer's disease progresses, soluble amyloid beta aggregates in the brain can induce the activation of microglia, which triggers synthesis of pro-inflammatory mediators. This leads to increased Chi3l1 expression in astrocytes. There is evidence that YKL-40 levels … See more It is assumed that YKL-40 plays a role in cancer cell proliferation, survival, invasiveness and in the regulation of cell-matrix interactions. It is suggested that YKL-40 is a marker … See more • Human CHI3L1 genome location and CHI3L1 gene details page in the UCSC Genome Browser. See more • Rathcke CN, Vestergaard H (June 2006). "YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis". Inflammation Research. 55 (6): 221–7. doi:10.1007/s00011-006-0076-y See more WebDec 20, 2005 · PTHR11177:SF202 CHITINASE-3-LIKE PROTEIN 1 1 hit; PROSITE. View protein in PROSITE; PS51910 GH18_2 1 hit; Pfam. View protein in Pfam; PF00704 Glyco_hydro_18 1 hit; SMART. View protein in SMART; SM00636 Glyco_18 1 hit; SUPFAM. SSF51445 (Trans)glycosidases 1 hit; SSF54556 Chitinase insertion domain 1 hit; MobiDB. nautilus investor relations