WebMay 24, 2024 · Docetaxel resistance seriously affects its clinical application in prostate cancer (PCa). Ferroptosis is a type of iron-dependent cell death driven by lipid … WebMay 20, 2024 · The mechanism of ferroptosis mainly relies on intracellular dynamically balanced biochemical processes: the production and elimination of lipid peroxides. In these processes, iron and polyunsaturated fatty acids (PUFAs) are used as raw materials for lipid peroxidation to promote ferroptosis.
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WebFerroptosis is a newly identified form of regulated cell death and is mainly driven by iron-mediated oxidative damage, ... Results showed that patients in the high-risk group had lower IC50s of cisplatin, doxorubicin, gemcitabine, mitomycin C, etoposide, and paclitaxel than those in the low-risk group, which suggested that patients with high ... WebNov 1, 2024 · Many natural products have been reported to promote cancer cell sensitivity to chemotherapeutics by interfering with the interaction of ferroptosis and autophagy. Zhou et al. reported that Chrysin induces autophagy-dependent ferroptosis to increase chemosensitivity to gemcitabine by targeting CBR1 in pancreatic cancer cells [55].
WebApr 15, 2024 · Ferroptosis is a form of regulated cell death driven by oxidative injury promoting lipid peroxidation, although detailed molecular regulators are largely … WebMar 16, 2024 · Gemcitabine is the first-line adjuvant chemotherapeutic drug for pancreatic cancer. Here, we found that both SLC7A11 and SLC3A2 are upregulated in …
WebAug 29, 2024 · It is tightly coupled to the regulation of protein interactions, trafficking, degradation, and enzymatic activities, thereby affecting a wide spectrum of cellular processes, including ferroptosis, lysosomal degradation, DNA repair, apoptosis, and other diverse processes 15-17. WebApr 12, 2024 · Ferroptosis combined with immunity shows a pivotal role in a variety of tumors, which provides new opportunities to detect and treat breast cancer.Methods: Our first step was to combine multiple datasets to search for immune ferroptosis-related mRNAs. ... Doxorubicin, Cisplatin, Gemcitabine, Gefitinib, Imatinib, Vinorelbine) in …
WebGemcitabine (GEM), an antimetabolite that terminates DNA synthesis, is commonly used in the treatment of cancers including lung adenocarcinoma (LUAD). However, downregulation of sensitivity limits the therapeutic effect.
WebGemcitabine (GEM) was employed to promote ferroptosis, and ferroptosis levels were determined by monitoring lipid reactive oxygen species (ROS), cell survival, and intracellular Fe 2+ concentrations. To assess in vivo tumor response to GEM therapy, a xenograft tumor mouse model was utilized. shoe styles menWebApr 1, 2024 · Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. shoe styles this yearWeb1 day ago · The high expression of RRM2 and AURKA leads to poor prognosis, so more sensitive agents are needed to improve outcome and try to connect these drugs with ferroptosis therapy of LUAD at this time. Zhan et al. concluded that RRM2 is closely related to the drug resistance of many chemotherapeutic drugs [43], such as gemcitabine [44]. … shoe styles sold at payless shoe storeWebMay 13, 2024 · Ferroptosis is a novel and unique non-apoptotic cell death form, which is different from apoptosis, necrosis and autophagy, involving iron-dependent ROS formation and lipid oxidation (Yang and Stockwell, 2016). Activation of ferroptosis observed in cancer contributed to destroying the cancer cells (Dixon et al., 2012). shoe subscribeWebGemcitabine and cisplatin are commonly used in chemotherapy, however, these drugs may cause severe cytotoxic side effects. Theophylline and aminophylline are commonly used as anti-asthma drugs and can block anti-phosphodiesterase activity. shoe styles of the 90sWebMar 4, 2024 · Accumulating studies have implicated that dysfunctional ferroptosis is involved in the progression of numerous human diseases and pathogenic processes 12, including carcinogenesis,... shoe styles of the 1950sWebMany chemotherapeutic drugs can induce ferroptosis in addition to their primary action (e.g., cisplatin, gemcitabine, sorafenib); in preclinical cancer models their action is increased by co-treatment with ferroptosis inducers, such as drugs that inhibit System Xc −, reduce GSH, inhibit GPX4, or alter intracellular iron levels (Su et al ... shoe styles trending for women