Genetically proxied
WebNov 15, 2024 · Background: Previous studies have found that statins may play a potential role in the age at onset (AAO) of Huntington’s disease (HD). We performed this Mendelian randomization (MR) study to assess the association between genetically proxied inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and low-density … WebMar 29, 2024 · Genetically proxied plasma TG levels and phenome-wide disease risk In the discovery analysis, we identified nominally significant associations (p<0.05) between plasma TG levels and 598 disease traits in UKB ( Supplementary file 1 ).
Genetically proxied
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WebMar 29, 2024 · Results Genetically proxied sildenafil was associated with fathering 0.21 (95% CI: 0.08– 0.35) more children (FDR corrected p = 0.01). This association was neither attenuated when adjusting for traits associated with our instruments nor was it replicated in women. We did not find robust evidence for an effect of sildenafil on the age of first … WebOutcome data was taken from the largest available GWAS of 6,034 oral and oropharyngeal cases, with 6,585 controls. We found limited evidence of a causal effect of genetically proxied body mass index (OR IVW = 0.89, 95%CI 0.72-1.09, p = 0.26 per 1 SD in BMI (4.81 kg/m2)) on oral and oropharyngeal cancer risk.
WebOn this page you'll find 9 synonyms, antonyms, and words related to genetically, such as: constitutionally, intrinsically, naturally, by birth, congenitally, and immanently. QUIZ … WebDec 2, 2024 · Genetically predicted milk consumption was inversely associated with colorectal cancer risk in the combined analysis of the UK Biobank and FinnGen consortium (Fig. 1).The OR for each additional milk intake increasing allele was 0.95 (95% confidence interval [CI] 0.91–0.99; P = 0.009), without evidence of heterogeneity between estimates …
WebAug 7, 2024 · Genetically-proxied impaired GIPR signalling and risk of 6 cancers Miranda Rogers , Dipender Gill , Emma Ahlqvist , Tim Robinson , Daniela Mariosa , Mattias … WebApr 6, 2024 · This study evaluated genetically proxied angiotensin-converting enzyme (ACE) inhibition association with dementias. The results suggest an association between ACE inhibition and Alzheimer's disease. The results suggest an association between ACE inhibition and frontotemporal dementia. Those associations can be interpreted as …
WebAug 7, 2024 · Methods We examined the association of a missense variant in GIPR, rs1800437 (E354Q), shown to impair long-term GIPR signalling and lower circulating GIP concentrations, with risk of 6 cancers influenced by impaired glucose homeostasis. Summary genetic association data on breast, colorectal, endometrial, lung, pancreatic, …
WebGenetically proxied drugs associated with reduced risk of coronary artery disease were included in primary analysis. Genetic summary statistics of SBP and HCC were derived from publicly available large-scale genome-wide association studies in Europeans and East Asians, respectively. Expression quantitative trait loci (eQTLs) of drugs target ... bud\u0027s on the hudsonWebA genetic disorder is a health problem caused by one or more abnormalities in the genome.It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) … bud\\u0027s paint and body shopWebJan 11, 2024 · We used genetic variants robustly associated with circulating cytokines to estimate the association of genetically proxied inflammatory cytokine concentrations on risk of breast, endometrial, lung, ovarian and prostate cancer. We used outcome-data from large well-established consortia that were either publicly available or for which we had ... bud\\u0027s overhead door inc. waterboro meWebMar 24, 2024 · Using mediation MR, we explored proteomic mediators of the effects of genetically proxied IL-6 signaling on coronary artery disease (CAD), large artery atherosclerotic stroke (LAAS), and peripheral artery disease (PAD). For significant mediators, we tested associations of their circulating levels with incident cardiovascular … crisgalleryWebFeb 27, 2024 · To explore the associations of genetically proxied TYK2 inhibition with a wide range of disease outcomes and biomarkers to identify therapeutic repurposing opportunities, adverse effects, and biomarkers of efficacy.The loss-of-function missense variant rs34536443 in TYK2 gene was used as a genetic instrument to proxy the effect of … cris goodmanWebObjective To examine the association of genetically proxied morning diurnal preference with depression risk using mendelian randomization. Design, Setting, and Participants … crisgar orange park flWebApr 6, 2024 · This study evaluated genetically proxied angiotensin-converting enzyme (ACE) inhibition association with dementias. The results suggest an association between … cris good