WebProtein folding disorder. Extracellular accumulation of B-pleated fibrillar deposits of monocloncal immunoglobulin light chain fragments. Progressive accumulation leads to organ failure – kidneys, heart, liver, periph nerves. Natural history – 80% mortality at 2 years. Current prognosis – OS Approx 5 years with therapy and supportive care. WebLymphoma Biology; Mantle Cell; Marginal Zone; Mastocytosis; MDS; MGUS; MPN Diagnostics; Myelofibrosis; Myeloma; NLPHL; PMBCL; PNH; Primary CNS Lymphoma; …
Cutaneous marginal zone lymphoma DermNet
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (EMZL of MALT type) 1. Usually triggered by chronic antigen stimulation (infection or immune) of marginal zone B cells 2. Particular sites of disease associated with specific triggers 2.1. Gastric - H. Pylori and other helicobacter … See more Bloods 1. FBC, film, paraprotein, LDH, B2 microglobulin, DAT, Hep C, cryoglobulins, Hep B, HIV Imaging 1. CT / PET-CT staging 2. (MRI for orbits / salivary glands) Morphology / Histology 1. Core tissue biopsy 2. Bone … See more Extranodal 1. Gastric EMZL 1.1. Should always receive H. pylori eardication 1.2. Early stage H.pylori positive gastric EMZL may take weeks or up to one year to respond following … See more Extranodal MZL 1. Lugano & Paris staging systems (see guideline) 2. Gastric EMZL requires OGD with multiple site biopsies for staging, and response is assessed by GELA grading on … See more MALT-IPI (Extranodal) 1. Age >70, Anna Arbor Stage III/IV, Raised LDH. Reflects 5-year EFS HPLL (Splenic) 1. Hb, Plt, LDH, extrahilar LN See more WebMantle cell lymphoma (t11;14 translocation) or B-cell prolymphocytic leukaemia. EBV-LMP1. EBV driven lymphomas. EMA (CD66a) Plasma cells +ve in anaplastic and large cell lymphoma. HLA DR . AML, ALL, Activated T-cells. Kappa / lambda. Difficult to do technically – best done by in situ hybridisation. KIR (Killer Inhibitor Receptor) NK Cells startengine owners bonus
Marginal Zone Lymphoma: Symptoms, Causes, and Outlook
WebHaemochromatosis (Genetic) — HaemBase Genetic haemochromatosis (Bsh 2024) Intro One of the most frequent genetic disorders in North Europeans Continued absorption of iron from the small intestine despite normal/high total body iron levels leads to tissue iron deposition and subsequent organ dysfunction. WebET — HaemBase Essential Thrombocythaemia (ET) (BSH 2010/2014/2024) 50-60% JAK2 V617F 25-30% CALR 3-11% MPL 12-17% ‘Triple Negative’ WHO 2016 Diagnostic Criteria Requires all major or 1-3 + the minor … peter\u0027s pizza loughborough