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WebMethadone is a unique opioid that may provide several important potential benefits for the patient in the perioperative period. It is a potent μ-receptor agonist with a rapid onset (6–8 minutes) and the longest half-life (24–36 hours) of the clinically-used opioids. 2 When used in larger doses, the clinical effect is terminated by systemic ... WebExisting risk scores, such as the American Society of Anesthesiologists (ASA) physical status score 10 and the Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity (POSSUM) scoring system, which have been externally validated for predicting the probability of in-hospital mortality after surgery have ... WebPostoperative opioid-induced respiratory depression (RD) is a significant cause of death and brain damage in the perioperative period. The authors examined anesthesia closed malpractice claims associated with RD to determine whether patterns of injuries could guide preventative strategies. Methods: fitzy\u0027s waterford hotel